MEG3 long noncoding RNA regulates the TGF-b pathway genes through formation of RNA–DNA triplex structures
نویسندگان
چکیده
MEG3 long noncoding RNA regulates the TGF-b pathway genes through formation of RNA–DNA triplex structures Tanmoy Mondal1, Santhilal Subhash1, Roshan Vaid1, Stefan Enroth2, Sireesha Uday1, Björn Reinius1, Sanhita Mitra1, Arif Mohammed1, Alva Rani James1, Emily Hoberg3, Aristidis Moustakas4,5, Ulf Gyllensten2, Steven J.M. Jones6, Claes M. Gustafsson3, Andrew H. Sims7, Fredrik Westerlund8, Eduardo Gorab9 & Chandrasekhar Kanduri1
منابع مشابه
MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures
Long noncoding RNAs (lncRNAs) regulate gene expression by association with chromatin, but how they target chromatin remains poorly understood. We have used chromatin RNA immunoprecipitation-coupled high-throughput sequencing to identify 276 lncRNAs enriched in repressive chromatin from breast cancer cells. Using one of the chromatin-interacting lncRNAs, MEG3, we explore the mechanisms by which ...
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